Publications by authors named "S L Brody"

Article Synopsis
  • Pulmonary fibrosis involves immune cell activity and fibroblast expansion, with CCR2+ monocytes playing a key role in its progression.
  • In mouse models, both an oral CCR2 inhibitor and the antifibrotic drug nintedanib reduced lung CCR2+ cells and fibrosis, indicating potential for using CCR2 inhibition as a treatment strategy.
  • CCR2-PET imaging could serve as a valuable tool for monitoring treatment responses and guiding patient management in pulmonary fibrosis.
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Background And Objective: Severe asthma is a heterogeneous disease with subtype classification according to dominant airway infiltrates, including eosinophilic (Type 2 high), or non-eosinophilic asthma. Non-eosinophilic asthma is further divided into paucigranulocytic or neutrophilic asthma characterized by elevated neutrophils, and mixed Type 1 and Type 17 cytokines in the airways. Severe non-eosinophilic asthma has few effective treatments and many patients do not qualify for biologic therapies.

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Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. Here we report that SARS-CoV-2 replication is restricted at a post-entry step in a number of ACE2-positive airway-derived cell lines due to tonic activation of the cGAS-STING pathway mediated by mitochondrial DNA leakage and naturally occurring cGAS and STING variants. Genetic and pharmacological inhibition of the cGAS-STING and type I/III IFN pathways as well as ACE2 overexpression overcome these blocks.

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Article Synopsis
  • Scientists found a new medicine called NuP-4 that helps repair lung damage caused by viruses.
  • This medicine works by blocking a special protein called MAPK13, which has a big role in making lung cells change and heal after injury.
  • Researchers showed that NuP-4 can keep helping even after stopping the treatment, and it also helps reduce inflammation and make things better in cells from both mice and humans.
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