Publications by authors named "S L Bonifacio"

Objective: To assess variability among data elements collected among existing neonatal hypoxic-ischemic encephalopathy (HIE) data registries worldwide and to determine the need for future harmonization of standard common data elements.

Study Design: This was a cross-sectional study of data elements collected from current or recently employed HIE registry data forms. Registries were identified by literature search and email inquiries to investigators worldwide.

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Article Synopsis
  • The study aims to predict the likelihood of death or severe neurodevelopmental impairment (NDI) in neonates with hypoxic-ischemic encephalopathy (HIE) who undergo hypothermia treatment.
  • The research involved 424 neonates from U.S. neonatal intensive care units, tracking their outcomes up to the age of 2 years, with a focus on clinical indicators taken 24 hours after birth.
  • Findings revealed that specific clinical characteristics, including severely abnormal EEG, low pH, and a poor Apgar score, can effectively signal high risk for severe outcomes, offering a high level of specificity and predictive value for clinicians.
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Background And Objectives: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal morbidity and mortality. Therapeutic hypothermia (TH), a proven treatment of moderate-severe HIE, was first used clinically after 2006. We describe trends in HIE diagnosis and use of TH over a 10-year period in California.

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Discussing homology relationships among secretory structures remains a relatively underexplored area in botanical research. These structures are widely dispersed within Malpighiales, one of the largest orders of eudicots. Within Malpighiales, both extranuptial and nuptial nectaries are present, and they do not seem homoplastic or share evolutionary connections.

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Background: 'Neonatal encephalopathy' (NE) describes a group of conditions in term infants presenting in the earliest days after birth with disturbed neurological function of cerebral origin. NE is aetiologically heterogenous; one cause is peripartum hypoxic ischaemia. Lack of uniformity in the terminology used to describe NE and its diagnostic criteria creates difficulty in the design and interpretation of research and complicates communication with families.

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