Publications by authors named "S L Beal"

Residue of energetic formulations, which is deposited on military training grounds following incomplete detonation, poses biotic hazards. This residue can be transported off-site, adsorb to soil clays and organic matter, transform or degrade, or taken up by plants and animals. Its harmful effects can be mitigated by localizing the energetics at the site of initial deposition using soil amendments and allowing them to bio- and photodegrade in situ.

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The explosive formulations IMX-101 and IMX-104 are replacing conventional explosives in munitions, making them safer to transport and handle. However, munitions manufacturing and military training can lead to the environmental release of constituent insensitive munitions compounds (IMCs) such as 2,4-dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), and nitroguanidine (NQ). These IMCs absorb ultraviolet light and transform photochemically into products with potentially greater toxicity.

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Article Synopsis
  • Repeat expansions in the C9orf72 gene are a leading genetic cause of ALS and frontotemporal dementia, but understanding how this mutation causes neuron death is still unclear, complicating the search for effective therapies.
  • Researchers analyzed data from over 41,000 ALS and healthy samples to identify potential treatments, discovering that acamprosate, a drug used for other conditions, might be repurposed for C9orf72-related diseases.
  • Their findings demonstrated that acamprosate has neuroprotective properties in cell models and works similarly well as the current treatment, riluzole, showing the potential of using genomic data to find new drug applications.
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Compelling evidence shows that social risks and mental health are intertwined. Pediatric clinicians can maximize the effectiveness of interventions that address mental health concerns by incorporating social risks and social needs screening and interventions. Approaches that elevate the interconnectedness of social risks and mental health require (a) an understanding of the multi-level contextual factors that contribute to patient and family functioning; and (b) a culturally responsive and multidisciplinary clinical practice that targets contextual factors.

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  • Children in foster care face increased behavior problems due to trauma and social changes, which can lead to placement disruptions if not addressed properly.
  • This study tests the effectiveness of the Chicago Parent Program adapted for foster caregivers (CPP-FC), aimed at improving caregiver stress, parenting skills, child behaviors, and placement stability.
  • 300 caregivers will be involved, with half receiving the CPP-FC intervention and the other half receiving usual care, and various assessments will be conducted to measure the program's impact on behaviors and placements over time.*
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