Publications by authors named "S Kwek"
Background: Singapore's large aging population poses significant challenges for the health care system in managing cognitive decline, underscoring the importance of identifying and implementing effective interventions. Cognitive training delivered remotely as a digital therapeutic (DTx) may serve as a scalable and accessible approach to overcoming these challenges. While previous studies indicate the potential of cognitive training as a promising solution for managing cognitive decline, understanding the attitudes and experiences of older adults toward using such DTx platforms remains relatively unexplored.
View Article and Find Full Text PDFBackground: Interprofessional collaborative care such as a split-shared care model involving family physicians and community pharmacists can reduce the economic burden of diabetes management. This study aimed to evaluate the economic outcome of a split-shared care model between family physicians and community pharmacists within a pharmacy chain in managing people with uncontrolled type 2 diabetes and polypharmacy.
Method: This was a multi-center, parallel arm, open label, randomized controlled trial comparing the direct and indirect economic outcomes of people who received collaborative care involving community pharmacists (intervention) versus those who received usual care without community pharmacist involvement (control).
Article Synopsis
- - Multiple myeloma often relapses after traditional treatments, but CAR T-cell therapy targeting BCMA shows promise, with over 70% of patients responding initially; however, most will relapse.
- - Patients with longer-lasting responses to CAR T-cell treatment tend to have more persistent CAR T cells and a higher presence of CD8+ T-effector memory cells compared to those with shorter responses, who have more exhausted cytotoxic CD4+ CAR T cells.
- - Nonclassical monocytes in the myeloma environment may contribute to CAR T-cell dysfunction and disease progression, highlighting the complex interactions at play in treatment resistance.
The fields of precision and personalised medicine have led to promising advances in tailoring treatment to individual patients. Examples include genome/molecular alteration-guided drug selection, single-patient gene therapy design and synergy-based drug combination development, and these approaches can yield substantially diverse recommendations. Therefore, it is important to define each domain and delineate their commonalities and differences in an effort to develop novel clinical trial designs, streamline workflow development, rethink regulatory considerations, create value in healthcare and economics assessments, and other factors.
View Article and Find Full Text PDFUnderstanding the kinetics of dengue viruses in the bloodstream can provide insights into the clinical outcomes of the disease.
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