Publications by authors named "S Kuwao"
Papillary fibroelastoma (PFE) is a benign tumor that arises mostly from left-sided valves. PFE can cause stroke, and surgical resection may be needed. Lambl's excrescence (LE) is a filiform valvular lesion and is considered a possible cause of stroke.
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- - The study focused on improving intraoperative diagnosis of CNS tumors using a new technique called filter paper-assisted cell transfer (FaCT), which helps in preparing tumor samples for analysis without freezing artifacts.
- - FaCT smears were tested on 40 CNS tumors, proving to yield sufficient cell numbers and morphology for accurate diagnosis, even with limited tissue samples; diagnostic concordance rates were found to be comparable to traditional frozen sections.
- - The results indicate that combining FaCT smears with frozen sections increases diagnostic accuracy to 92.5%, showcasing FaCT as a simple and effective method for intraoperative CNS tumor diagnosis.
Aims: Alpha-fetoprotein (AFP)-producing gastric cancer (GC) is an aggressive tumour with high rates of liver metastasis and poor prognosis, and for which a validated chemotherapy regimen has not been established. Drug uptake by solute carrier (SLC) transporters is proposed as one of the mechanisms involved in sensitivity to chemotherapy. In this study, we aimed to develop important insights into effective chemotherapeutic regimens for AFP-producing GC.
View Article and Find Full Text PDFRapid immunocytochemistry (ICC) can improve the accuracy of intraoperative cytological diagnoses; however, it is usually applied without heat-induced antigen retrieval (HIAR). We established a HIAR method for rapid ICC and evaluated its efficacy and reliability. Rapidly fixed smear samples were immunostained using 35 antibodies.
View Article and Find Full Text PDFObjective: The aim of this study was to evaluate whether the immunocytochemical expression of cell proliferation markers, such as minichromosome maintenance protein 7 (MCM 7), geminin, topoisomerase II alpha (topo IIα) and Ki-67, which are different types of cell proliferation markers, could be useful for their differential diagnosis in reactive mesothelial cells and malignant mesothelioma cells obtained from body cavity fluids.
Study Design: Samples diagnosed and later histologically confirmed as reactive mesothelial cells (39 cases) or malignant mesothelioma (32 cases) in body cavity fluids were examined. Immunocytochemical staining of MCM 7, geminin, topo IIα and Ki-67 was performed with the immunoperoxidase polymer method.