Publications by authors named "S Kurosaki"
Key Clinical Message: In younger patients, including those with extensive infarction involving the anterior and middle cerebral artery regions of the right hemisphere, appropriate treatment for rare causes and goal-oriented long-term rehabilitation could improve severe hemiplegia and higher brain dysfunction, and allow for further education and employment.
Abstract: Although the number of young stroke patients is small, many have serious sequelae and rare causes. In addition to independence in activities of daily living, education and employment are desired.
Article Synopsis
- - Achiral 2-pyridone and 4-aminopyridine crystals acted as sources of chirality in a reaction involving 5-pyrimidyl alkanol, promoting asymmetric autocatalysis known as the Soai reaction.
- - During this process, diisopropylzinc was added to pyrimidine-5-carbaldehyde, leading to the creation of enantioenriched products.
- - The reaction resulted in a significant increase in enantiomeric excess, with the final 5-pyrimidyl alkanol mirroring the configurations of the original chiral crystals.
Background: Lenvatinib was expected to enhance the effect of immune checkpoint inhibitors (ICIs) for unresectable HCC; however, their combination therapy failed to show the synergy in the phase III clinical trial.
Methods: To elucidate lenvatinib-induced molecular modulation, we performed bulk RNA-sequencing and digital spatial profiling of 5 surgically resected human HCC specimens after lenvatinib treatment and 10 matched controls without any preceding therapy.
Findings: Besides its direct antitumor effects, lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tumor-associated macrophages, suggesting that lenvatinib-treated HCC is in the so-called excluded condition that can diminish ICI efficacy.
Article Synopsis
- Inhibition of sterol regulatory element-binding proteins (SREBPs) in the liver was found to worsen liver damage, fibrosis, and cancer progression in NASH models, despite reducing fat buildup.
- Research showed that blocking SREBPs disrupted fatty acid composition in liver cells, leading to stress and injury, which could be relieved by adding phosphatidylcholines.
- Findings suggest that while SREBP inhibition may seem beneficial for reducing fat, it can actually worsen NASH and indicate that treatments targeting lipogenesis need careful consideration.