Ultrastructure of liver in acute experimental pancreatitis in dogs treated with prostacyclin.

The ultrastructure of the liver was studied in 3 groups of dogs (5 in each) with acute experimental pancreatitis (AEP) induced by injection of bile-trypsin mixture into the pancreatic duct. Experiments were terminated after 12 h. In the group of untreated animals, severe degeneration of mitochondria, extensive autophagocytosis, hyperactivity of Kupffer cells, depletion of glycogen granules, dilatation of endoplasmic spaces and vacuolisation of cytoplasm were found.

[Histopathologic and biochemical evaluation of the effect of cortisone on the liver in experimental post-alcoholic liver damage in the rabbit].

Possible protective effects of cortisone in experimental post-alcohol liver damage were evaluated in relation to dose and duration of treatment. Model examinations were undertaken in 100 rabbits divided into groups of 10. No protective effect of cortisone could be demonstrated.