Publications by authors named "S Kupsch"
Article Synopsis
- ICU patients often undergo a stressful process of weaning from sedation and ventilation, and a study pilot-tested a coaching tool led by family members to help ease this transition for both patients and their families.
- Conducted in Calgary, the study involved 25 family-patient dyads from two ICUs, with surveys assessing family demographics, anxiety, tool feedback, and attitudes towards family presence during weaning trials.
- Results showed that 60% of families found the coaching tool useful, 70% reported positive experiences with family involvement, and family anxiety significantly decreased after using the tool.
Article Synopsis
- - Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder linked to sarcomere gene mutations, resulting in left ventricular thickening and diastolic dysfunction; new research emphasizes the importance of microtubule alterations in heart failure.
- - The study explored the effects of increasing tubulin tyrosination via adeno-associated virus transfer in various models, including HCM human cardiomyocytes and specific mouse models, revealing that this approach improved heart function by reducing harmful microtubule modifications and enhancing contractility.
- - Results indicated that enhancing tubulin tyrosination led to better heart function metrics such as contractility and cardiac output in both human and mouse models, while also suggesting potential benefits of targeting the micro
Nat Cardiovasc Res
January 2024
Article Synopsis
- Viral myocarditis involves the immune response to virus invasion, but the role of the GPR15 receptor in heart disease remains unclear.
- Researchers found that mice lacking GPR15 had trouble eliminating coxsackievirus B3, which resulted in harmful heart changes and dysfunction.
- The study suggests that GPR15 is crucial for the timely recruitment of regulatory T cells, and its absence leads to a prolonged inflammatory response and worse cardiac outcomes.
Article Synopsis
- - The study focuses on understanding how sociodemographic variables, like gender identity and systemic racism, influence health outcomes for critically ill adults, highlighting the need for better data collection in critical care research.
- - Researchers will perform a scoping review to identify essential sociodemographic measures and involve various stakeholders in a modified Delphi survey to reach a consensus on core data variables (CoDaV) for health studies in critical care.
- - The study has received ethical approval from the University of Calgary's research ethics board, ensuring that the process adheres to ethical standards and findings will be disseminated effectively.
