Publications by authors named "S Krzyzanowski"
Depression during and after pregnancy affects up to 20% of pregnant women, but the biological underpinnings remain incompletely understood. As pregnancy progresses, the immune system changes to facilitate fetal development, leading to distinct fluctuations in the production of pro-inflammatory factors and neuroactive tryptophan metabolites throughout the peripartum period. Therefore, it is possible that depression in pregnancy could constitute a specific type of inflammation-induced depression.
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- A study indicates that excess iron accumulation in the substantia nigra, a brain region affected in Parkinson's disease (PD), is linked to the loss of dopamine-producing neurons.
- Researchers found that PD patients had significantly lower levels of plasma serotonin and higher iron levels in the substantia nigra compared to controls.
- There is a notable correlation in PD patients between lower serotonin levels and higher nigral iron, suggesting a potential relationship that could aid understanding of early PD progression.
Background: The objective of this study was to determine whether neurotoxic kynurenine metabolites, induced by inflammation, in plasma and cerebrospinal fluid (CSF) are associated with symptom severity and nigral pathology in Parkinson's disease (PD).
Methods: Clinical and MRI data were obtained from 97 PD and 89 controls. We used ultra-performance liquid chromatography to quantify kynurenine metabolites and high-sensitivity multiplex assays to quantify inflammation in plasma and CSF.