Central nervous system complications of immune checkpoint inhibitors: A comprehensive review.

The ever-increasing use of immune checkpoint inhibitors (ICIs) has significantly improved cancer management, but at the cost of frequent immunologic side effects. Among them, neurologic immune-related adverse events (nirAEs) are less common but pose a challenge to clinicians due to their severity, heterogeneous nature and nonspecific clinical presentation, making diagnosis complex. The prognosis of these nirAEs, especially those related to the central nervous system (CNS), correlates with their rapid recognition and therapeutic management.

MRI management of NMOSD and MOGAD: Proposals from the French Expert Group NOMADMUS.

Background: Currently, there are no available recommendations or guidelines on how to perform MRI monitoring in the management of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The issue is to determine a valuable MRI monitoring protocol to be applied in the management of NMOSD and MOGAD, as previously proposed for the monitoring of multiple sclerosis.

Objectives: The objectives of this work are to establish proposals for a standardized and feasible MRI acquisition protocol, and to propose control time points for systematic MRI monitoring in the management of NMOSD and MOGAD.

High-fidelity anatomical phantoms for MRI practical training.

Introduction: Practical MRI training is essential for bridging the gap between complex theoretical knowledge and clinical applications. Traditional phantoms used in MRI, such as ACR phantoms, are valuable for illustrating system characterization methods but often lack the anatomical complexity required for realistic training. This study presents the development of high-fidelity anatomical phantoms designed specifically for practical MRI training.

A Simple Method for the Study of Heteroionic Interface Impedances in Solid Electrolyte Multilayer Cells Containing LLZO.

Hybrid battery cells that combine a garnet-type LiLaZrO (LLZO) solid electrolyte with other solid, polymer or liquid electrolytes are increasingly investigated. In such cells with layered electrolytes, ensuring a low-resistive heteroionic interface between neighboring electrolytes is crucial for preventing major additional overpotentials during operation. Electrochemical impedance spectroscopy is frequently used to extract such parameters, usually on multilayer symmetrical model cells that contain the different electrolytes stacked in series.

Endovascular thrombectomy in patients with anterior circulation stroke: an emulated real-world comparison.

Background: Endovascular thrombectomy (EVT) has been proven effective in anterior circulation stroke due to large vessel occlusion (LVO). However, translation from randomized clinical trials (RCTs) with highly selected patients to real-world requires confirmation, particularly to identify associations outside of strict selection criteria.

Aims: This study aims to compare functional outcomes after EVT in real-world with those reported in RCTs, and to identify associations with functional outcome after EVT outside RCT-criteria.