Impact of active intra-complex rest intervals on post-back squat versus hip thrust jumping potentiation.

This study investigated the impact of active rest intervals within a lower body complex training session on post-activation performance enhancement (PAPE) response in amateur soccer players. Twelve soccer players took part in four different experimental conditions. These sessions included 2 sets of lower body complex-paired exercises, each involving 3 repetitions of either back squats or hip thrusts at 90% one-repetition maximum (1RM) as a conditioning activity paired with a broad jump and countermovement jump.

Investigating the Readability and Linguistic, Psychological, and Emotional Characteristics of Digital Dementia Information Written in the English Language: Multitrait-Multimethod Text Analysis.

Background: Past research in the Western context found that people with dementia search for digital dementia information in peer-reviewed medical research articles, dementia advocacy and medical organizations, and blogs written by other people with dementia. This past work also demonstrated that people with dementia do not perceive English digital dementia information as emotionally or cognitively accessible.

Objective: In this study, we sought to investigate the readability; linguistic, psychological, and emotional characteristics; and target audiences of digital dementia information.

Efficacy of Adeno-Associated Virus Serotype 9-Mediated Gene Therapy for AB-Variant GM2 Gangliosidosis.

GM2 gangliosidoses are a group of neurodegenerative lysosomal storage disorders that are characterized by the accumulation of GM2 gangliosides (GM2), leading to rapid neurological decline and death. The hydrolysis of GM2 requires the specific synthesis, processing, and combination of products of three genes-, , and -within the cell's lysosomes. Mutations in these genes result in Tay-Sachs disease, Sandhoff disease, or AB-variant GM2 gangliosidosis (ABGM2), respectively.

Effect of silymarin on the relative gene expressions of some inflammatory cytokines in the liver of CCl-intoxicated male rats.

The intensive exposure of the liver cells to any type of noxae, such as viruses, drugs, alcohols, and xenobiotics could induce hepatic inflammation through the upregulation of gene expression of several fibrotic and inflammatory mediators. So, our study assessed the role of silymarin on the inflammatory response induced by carbon tetrachloride (CCl) as an example of xenobiotics on liver tissues in male rats. Forty-eight Wister male rats (weight: 130 ± 10) were housed for 14 days and then divided randomly into six groups: control, SLY: rats received only silymarin orally for 12 weeks (daily), CO: rats were injected with corn oil for 8 weeks (3 times weekly), CCl: rats were injected with CCl solubilized in corn oil for 8 weeks (day by day), Treated: rats received silymarin for 4 weeks after CCl injection, Protected: rats received silymarin for 4 weeks before and 8 weeks during CCl injection.