Publications by authors named "S Kossmann"
Objective: A novel small form factor circular electrode array was designed specifically for electrical impedance tomography (EIT) based assessment of surgical margins during robot assisted radical prostatectomy (RARP).
Methods: The electrode array consists of 33 gold-plated electrodes arranged within a 9.5 mm diameter circular footprint on the end of a surgical probe that can be introduced through a standard 12 mm laparoscopic port used during RARP.
Patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD) have a low one-year survival rate. Identification and validation of novel targetable kinases in patients who experience corticosteroid-refractory-aGVHD may help improve outcomes. Kinase-specific proteomics of leukocytes from patients with corticosteroid-refractory-GVHD identified rho kinase type 1 (ROCK1) as the most significantly upregulated kinase.
View Article and Find Full Text PDFInvariant natural killer T cells are a rare, heterogeneous T-cell subset with cytotoxic and immunomodulatory properties. During thymic development, murine invariant natural killer T cells go through different maturation stages differentiating into distinct sublineages, namely, invariant natural killer T1, 2, and 17 cells. Recent reports indicate that invariant natural killer T2 cells display immature properties and give rise to other subsets, whereas invariant natural killer T1 cells seem to be terminally differentiated.
View Article and Find Full Text PDFArticle Synopsis
- Microvascular thrombosis and inflammation (thromboinflammation) are serious issues for critically ill patients, as they lead to high mortality rates and limited treatment options.
- The research introduces a new microfluidic post model that simulates 3D interactions between neutrophils and platelets, providing a better understanding of their behavior in a flow environment compared to traditional 2D methods.
- The study findings indicate that the geometry of the posts significantly affects neutrophil recruitment and adhesion, suggesting that 3D platelet formations play a crucial role in enhancing inflammatory responses in microvascular conditions.
Aims: Assessment of endothelial function in humans by measuring flow-mediated dilation (FMD) risk-stratifies individuals with established cardiovascular disease, whereas its predictive value is limited in primary prevention. We therefore aimed to establish and evaluate novel markers of FMD at the population level.
Methods And Results: In order to identify novel targets that were negatively correlated with FMD and investigate their contribution to vascular function, we performed a genome-wide association study (GWAS) of 4175 participants of the population based Gutenberg Health Study.