Publications by authors named "S Koskiniemi"
Antimicrobial resistance (AMR) is an increasing problem worldwide, and new treatment options for bacterial infections are direly needed. Engineered probiotics show strong potential in treating or preventing bacterial infections. However, one concern with the use of live bacteria is the risk of the bacteria acquiring genes encoding for AMR or virulence factors through horizontal gene transfer (HGT), and the transformation of the probiotic into a superbug.
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- Contact-dependent growth inhibition (CDI) is a competitive strategy used by bacteria, particularly mediated by proteins called CdiA, which inject toxic regions into neighboring cells to inhibit their growth.
- CdiA is made up of two distinct domains: the C-terminal ionophore domain, which forms a structure capable of crossing cell membranes, and an N-terminal entry domain that can vary in structure and function, allowing the toxin to insert into other bacteria.
- Researchers have identified various receptor proteins for these toxins, with significant diversity in immunity proteins (CdiI) that provide protection against specific toxins, highlighting a complex and highly specific interaction network among bacterial species.
Aim: To investigate nurses' and other users' perceptions and knowledge regarding patient safety incident reporting software and incident reporting.
Design: A cross-sectional online survey.
Methods: The survey, 'The Users' Perceptions of Patient Safety Incident Reporting Software', was developed and used for data collection January-February 2024.
Dicytostelium firmibasis is a member of Dictyostelia, a group of social amoebae that upon starvation display aggregative multicellularity where the amoebae transition from uni- to multicellular life. The D. firmibasis genome assembly that is currently available is of limited use due to its low contiguity, large number of undetermined bases, and lack of annotations.
View Article and Find Full Text PDFBackground: Taxonomies are needed for automated analysis of clinical data in healthcare. Few reviews of the taxonomy development methods used in health sciences are found. This systematic review aimed to describe the scope of the available taxonomies relative to patient safety, the methods used for taxonomy development, and the strengths and limitations of the methods.
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