Publications by authors named "S Koljenovic"
Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory infiltrate. Herein, we report 25 unpublished cases of SMEC, two of them with prominent eosinophilia (2/25; 8%) and three with abundant IgG4-positive plasma cells (3/25; 12%). In our series of salivary SMEC, molecular analysis using fluorescence in situ hybridization (FISH) and/or next-generation sequencing (NGS) provided evidence of MAML2 gene rearrangement in 18 cases of the 21 analyzable cases tested (86%), while this gene locus was intact in 3 cases (14%).
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- The study investigates the use of fluorescence imaging (FLI) to enhance the surgical identification of oral and laryngeal cancers (OSCC and LSCC) and papillary thyroid carcinoma (PTC), aiming to improve excision precision due to challenges in tumor delineation.
- Six potential tumor-targeting markers were evaluated through immunohistochemical staining in various cancer samples, with integrin αvβ6 and EGFR showing significant overexpression in OSCC and LSCC, indicating their effectiveness as FLI targets.
- The research suggests that although PTC shows lower expressions of these markers, the notable overexpression of VEGF-α and c-Met could also make them viable for improving
Standardised definitions and diagnostic criteria for extranodal extension detected on histopathological examination in head and neck cancer: Head and Neck Cancer International Group consensus recommendations.
Lancet Oncol
July 2024
Article Synopsis
- Detection of extranodal extension (ENE) in head and neck squamous cell carcinoma indicates a poor prognosis, but there's currently a lack of standardized diagnostic criteria and reporting methods in the literature.
- The Head and Neck Cancer International Group organized a modified Delphi process involving 19 pathology experts to establish consensus recommendations for diagnosing and reporting ENE.
- The resulting guidelines, supported by 19 organizations from 34 countries, aim to standardize the diagnosis and improve accuracy in data collection regarding histology detected extranodal extension.
Background: Resection margins are an important prognostic factor for patients with head and neck cancer. In general, for head and neck surgery, a margin >5 mm is advised by the Royal College of Pathologists. However, this cannot always be achieved during laryngeal and hypopharyngeal surgery.
View Article and Find Full Text PDFBackground: Laryngeal and hypopharyngeal cancer is complex and resection margins are therefore constrained. The aim of this study was to investigate the clinical relevance of resection margins in laryngeal and hypopharyngeal surgery.
Methods: A retrospective cohort study was performed for patients treated with a total laryngectomy (TL) or laryngopharyngectomy (TLP) for laryngeal or hypopharyngeal squamous cell carcinoma (LSCC and HSCC, respectively).