Publications by authors named "S Kohsaka"
This study aims to compare 1-year outcomes after transcatheter aortic valve replacement (TAVR) between patients with moderate-severe MR and severe MR preoperatively using the Japan Transcatheter Valve Therapy (J-TVT) registry. Patients undergoing TAVR for aortic stenosis between August 2013 and December 2019 with preoperative mitral regurgitation of moderate-severe (group MR3) or severe (group MR4) were included. Patients with a history of valve surgery and dialysis patients were excluded.
View Article and Find Full Text PDFBackground: The third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib is widely used as a first-line treatment for -mutated non-small cell lung cancer (NSCLC). However, there is no established treatment for osimertinib resistance, so second-generation afatinib is an alternative treatment option. The purpose of this study was to elucidate gene alterations associated with afatinib efficacy and resistance by analyzing cell-free DNA (cfDNA) obtained from patients with -mutated NSCLC.
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- Diabetes is a significant risk factor for cardiovascular diseases but exhibits a "diabetes paradox" in Takotsubo syndrome, where it may not negatively affect outcomes, although this remains debated.
- In a study analyzing 1,226 Takotsubo syndrome patients, the prevalence of diabetes was found to be similar to that of the general population (17.0% vs. 15.8%).
- The study concluded that diabetes does not have a protective effect in Takotsubo syndrome and may even be linked to higher in-hospital mortality rates, challenging the belief that diabetes could be beneficial in this context.
Article Synopsis
- Multidisciplinary self-care education is vital for managing hospitalized heart failure (HF) patients, and the study examines if confidence in self-care during hospitalization impacts post-discharge performance and outcomes.
- Researchers assessed 100 HF patients' self-care confidence and behaviors during hospitalization and one year post-discharge, using questionnaires and logistic regression analysis to find links between self-care confidence, performance, and long-term health outcomes.
- Results showed that low self-care confidence during hospitalization led to poor post-discharge self-care performance, particularly affecting patients with reduced ejection fraction and those with previous HF hospitalizations, but overall, post-discharge self-care behavior did not significantly impact 2-year mortality and readmission rates.