Publications by authors named "S Kochhar"
: The Measles-Rubella Microarray Patch (MR-MAP) is an important technology that is expected to reduce coverage and equity gaps for measles-containing vaccines (MCVs), reach zero-dose children, and contribute to elimination of measles and rubella. MR-MAPs are anticipated to be easier to deploy programmatically and could be delivered by lesser-trained health workers, thereby increasing immunization coverage. The most advanced MR-MAP has reached clinical proof-of-concept through a Phase I/II trial in the target population of infants and young children.
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- * A study involving 100 first-year MBBS students assessed their BLS knowledge and skills before and after training, plus evaluations at one month, six months, and one year later.
- * Results showed significant initial improvement in knowledge and skills, but retention declined notably after six months, suggesting the need for periodic refresher training to maintain competence in BLS.
Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA splicing regulators ESRP1 and ESRP2 regulate craniofacial morphogenesis and their disruption result in OFC in zebrafish, mouse and humans. Using esrp1/2 mutant zebrafish and murine Py2T cell line models, we functionally tested the pathogenicity of human ESRP1/2 gene variants.
View Article and Find Full Text PDFBackground: Schizophrenia is a severe mental illness that greatly impacts the real-world functioning of patients. In India, caregivers are primarily responsible for their patients and function as their support system, often taking treatment decisions on their behalf. However, they may have insufficient knowledge of the illness, which can have a negative impact on their roles as effective caregivers.
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- Orofacial cleft (OFC) is a common birth defect linked to disruptions in specific RNA splicing regulators that affect craniofacial development.
- Using mutant zebrafish and mouse cell models, researchers found that many gene variants thought to cause OFC were actually harmless, emphasizing the need for thorough testing of these variants.
- The study identified 13 genetic variants from OFC patients, confirming the critical role of a specific gene in human OFC and showing that its proper functioning is essential for healthy embryonic oral development.