Publications by authors named "S Knuutila"
Article Synopsis
- - The study analyzed stool samples from colorectal cancer patients to compare hotspot mutations between Iranian and Finnish populations.
- - The Iranian group had 35 distinct mutations, while the Finnish group showed 13 mutations; some mutations were unique to each cohort.
- - Higher mutation frequencies were found in genes related to MAPK and PI3K-MAPK pathways in the Iranian cohort, suggesting potential implications for treatment strategies.
Pancreatic cancer (PC) is an aggressive malignancy with a dismal prognosis. To improve patient survival, the development of screening methods for early diagnosis is pivotal. Oncogenomic alterations present in tumor tissue are a suitable target for non-invasive screening efforts, as they can be detected in tumor-derived cells, cell-free nucleic acids, and extracellular vesicles, which are present in several body fluids.
View Article and Find Full Text PDFPancreatic cancer (PC) is an aggressive disease with a high mortality and poor prognosis. The human microbiome is a key factor in many malignancies, having the ability to alter host metabolism and immune responses and participate in tumorigenesis. Gut microbes have an influence on physiological functions of the healthy pancreas and are themselves controlled by pancreatic secretions.
View Article and Find Full Text PDFArticle Synopsis
- Gastric adenocarcinoma is linked to H. pylori infection and changes in gut microbiota, but the relationship with different tumor types and intestinal microbiota is not well understood, prompting a study of Finnish patients' stool samples.
- Results indicated that patients with diffuse adenocarcinoma had the lowest gut microbiota diversity, while significant differences in microbiota composition were found across all tumor types compared to healthy controls, particularly with increased Enterobacteriaceae.
- The study suggests that higher levels of Enterobacteriaceae could serve as a potential marker for gastric tumors, and reduced gut microbiota diversity may indicate more aggressive cancer forms, serving as a possible prognostic indicator.