Participant diversity is necessary to advance brain aging research.

An absence of population-representative participant samples has limited research in healthy brain aging. We highlight examples of what can be gained by enrolling more diverse participant cohorts, and propose recommendations for specific reforms, both in terms of how researchers accomplish this goal and how institutions support and benchmark these efforts.

Biopsychosocial contributors to irritability in individuals with shoulder or low back pain.

Objectives: Irritability is a foundational clinical reasoning concept in rehabilitation to evaluate reactivity of the examination and treatment. While originally theorized to reflect tissue damage, a large body of evidence supports pain is a biopsychosocial experience impacted by pain sensitivity and psychological factors. Therefore, the purpose of this study was to examine biopsychosocial contributors to irritability.

Low-dose aspirin as primary prevention for adults without cardiovascular disease.

Background: Cardiovascular disease is the leading cause of death in the United States. Patients with cardiovascular disease risk factors are often put on low-dose aspirin to prevent future cardiovascular events and cardiovascular death. However, the evidence supporting this practice is limited.

Disrupted Choline Clearance and Sustained Acetylcholine Release by a Common Choline Transporter Coding Variant Associated with Poor Attentional Control in Humans.

Transport of choline via the neuronal high-affinity choline transporter (CHT; ) is essential for cholinergic terminals to synthesize and release acetylcholine (ACh). In humans, we previously demonstrated an association between a common CHT coding substitution (rs1013940; Ile89Val) and reduced attentional control as well as attenuated frontal cortex activation. Here, we used a CRISPR/Cas9 approach to generate mice expressing the I89V substitution and assessed, , CHT-mediated choline transport, and ACh release.