Publications by authors named "S Klaus"
Recent research has identified growth differentiation factor 15 (GDF15) as a crucial factor in various physiological and pathological processes, particularly in energy balance regulation. While the role of GDF15 in modulating energy metabolism through hindbrain GDNF family receptor alpha-like (GFRAL) signaling has been extensively studied, emerging evidence suggests direct peripheral metabolic actions of GDF15. Using knockout mouse models, we investigated GDF15 and GFRAL's roles in adipose tissue metabolism.
View Article and Find Full Text PDFExpansion microscopy has recently emerged as an alternative technique for achieving high-resolution imaging of biological structures. Improvements in resolution are achieved by physically expanding samples through embedding in a swellable hydrogel before microscopy. However, expansion microscopy has been rarely used in the field of virology.
View Article and Find Full Text PDFImpact of Psoas Muscle Area Index on Short- and Mid-Term Mortality in Patients Undergoing Valve Surgery for Infective Endocarditis: A Retrospective Analysis.
Diagnostics (Basel)
October 2024
Article Synopsis
- Sarcopenia, which leads to reduced skeletal muscle mass, is linked to poor outcomes in cardiovascular surgeries, especially in valve surgery for infective endocarditis (IE).
- This study analyzed 68 patients who underwent valve surgery to explore the connection between sarcopenia (measured using the Psoas muscle area index) and mortality rates.
- Findings revealed that sarcopenia significantly increased mortality risk at both 1-year and 3-year marks, with female sex, older age, chronic kidney insufficiency, and heart failure medications also impacting survival, emphasizing the need for routine assessments and tailored management in high-risk patients.
Article Synopsis
- The study introduces a new system called A-B-S2EBPR for efficient nitrogen removal from low-strength municipal wastewater by promoting nitrite accumulation.
- Researchers achieved significant nitrite levels (5.5 mg N/L) and high removal efficiency of total inorganic nitrogen (TIN at 84.9%) through a combination of biological processes.
- The findings highlight a shift in microbial communities that favor partial denitrification over conventional nitrification, with specific microorganisms utilizing carbon sources during the process.
Introduction: Alzheimer's disease, a progressive neurodegenerative disorder, is marked by beta-amyloid plaque accumulation and cognitive decline. The limited efficacy and significant side effects of anti-amyloid monoclonal antibody therapies have prompted exploration into innovative treatments like focused ultrasound therapy. Focused ultrasound shows promise as a non-invasive technique for disrupting the blood-brain barrier, potentially enhancing drug delivery directly to the brain and improving the penetration of existing therapeutic agents.
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