Publications by authors named "S Kitamura"
Objective: This study examines the impact of preoperative stress on postoperative neuroinflammation and associated cognitive dysfunction, with a focus on aged individuals. The goal is to determine whether managing preoperative stress can enhance postoperative outcomes and lower the risk of cognitive impairment.
Results: In aged rats, preoperative restraint stress significantly worsened neuroinflammation and cognitive deficits following abdominal surgery.
Article Synopsis
- * It finds that the frequency of SIV-Gag-specific follicular CD8 T cells is linked to the amount of SIV-RNA, particularly in treated or naturally controlling macaques, while showing a different behavior in untreated macaques.
- * The research indicates that the gene expression profile of fCD8 T cells in naturally controlled infections is more favorable compared to those under cART, suggesting that improving these cells may lead to potential curative strategies for HIV/SIV.
Hyphal elongation is the vegetative growth of filamentous fungi, and many species continuously elongate their hyphal tips over long periods. The details of the mechanisms for maintaining continuous growth are not yet clear. A novel short lifespan mutant of N.
View Article and Find Full Text PDFSoluble epoxide hydrolase (sEH) is a bifunctional enzyme involved in fatty acid metabolism and a promising drug target. We previously reported first-generation sEH proteolysis-targeting chimeras (PROTACs) with limited degradation potency and low aqueous and metabolic stability. Herein, we report the development of next-generation sEH PROTAC molecules with improved stability and degradation potency.
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