Publications by authors named "S Kishino"
Article Synopsis
- The study aimed to investigate whether maternal egg consumption during lactation can help prevent egg allergies in infants by promoting immune tolerance.
- Researchers collected data from mothers on their egg intake, breastfeeding practices, and infants' health, particularly looking at instances of eczema and allergies at 6 and 12 months.
- Results showed that maternal egg consumption did not significantly affect allergy development, but infants with eczema at 6 months had a higher risk of developing egg allergies by 12 months, highlighting the need to reduce skin exposure to allergens.
Non-covalent interactions offer an alternative way for developing stimulus-responsive materials such as sensors, machines, and drug-delivery systems. We recently reported that a urethane-equipped tetrakis(porphyrin) forms one-handed helical supramolecular polymers in solution in response to chirality of chiral solvents. Conformational changes in helical sense were detected using circular dichroism (CD) spectroscopy, which showed that the tetrakis(porphyrin) can possibly be used as a sensor for determining the enantiomeric excess of a chiral analyte.
View Article and Find Full Text PDFIntestinal bacteria metabolize dietary substances to produce bioactive postbiotics, among which some are recognized for their role in promoting host health. We here explored the postbiotic potential of two omega-3 α-linolenic acid-derived metabolites: -10--15-octadecadienoic acid (t10,c15-18:2) and -9--15-octadecadienoic acid (c9,c15-18:2). Dietary intake of lipids rich in omega-3 α-linolenic acid elevated levels of t10,c15-18:2 and c9,c15-18:2 in the serum and feces of mice, an effect dependent on the presence of intestinal bacteria.
View Article and Find Full Text PDFArticle Synopsis
- - Peroxisomes play a crucial role in oxidizing fatty acids, which is important for lipid synthesis and carbon recycling but does not directly produce ATP.
- - Genetic disorders causing the malfunction of peroxisomes lead to the accumulation of very long-chain fatty acids (VLCFAs), which serve as markers for these disorders, although their exact link to symptoms remains unclear.
- - Recent research developed a method to solubilize VLCFAs in water, showing that replenishing oleic acid can reduce the toxicity associated with VLCFA accumulation.
Article Synopsis
- Various gut bacteria can convert polyunsaturated fatty acids into different types of fatty acid derivatives, with γKetoC identified as a potent immunomodulator that inhibits inflammation and immune cell activation.
- γKetoC reduces the proliferation of CD4 T cells and the release of inflammatory cytokines in various immune cell types, indicating its potential therapeutic effects on inflammation.
- The study highlights the role of the NRF2 pathway and GPR40/120 receptors in mediating the anti-inflammatory responses of γKetoC, demonstrating improved outcomes in mice with colitis while showing adverse effects in NRF2-deficient mice.