Publications by authors named "S Kirubakaran"

Unlabelled: This study focusses on the health seeking behaviour of NCD patients which entails regularity of health care facility visitations and adherence to lifestyle modifications.

Aims: To analyse the hospital visitations and lifestyle modifications of NCD patients. To do a comparative study about the health seeking behaviour among NCD patients in Rural and Urban areas.

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The synthesis of a library of new biaryl-based carbazoles bidentate directing group-assisted C-H functionalization and preliminary screening of the anticancer properties of biaryl-based carbazoles is reported. While various classes of modified carbazoles are known for their applications in materials and medicinal chemistry, to our knowledge, the biological activities of designed biaryl-based carbazoles have been rarely known. Given the prominence of carbazoles in research in medicinal chemistry, we envisioned the scope for new scaffolds of carbazole-based biaryl structures.

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Establishing new medical schools in medically under-served regions is suggested as part of the solution to the problem of doctor shortages and maldistributions. Establishing a new medical school is, however, a complex undertaking with high financial and political stakes. Critically, the evidence-base for this significant activity has not previously been elucidated.

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Article Synopsis
  • Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with limited treatment options, and TMZ, the current standard drug, has been criticized for its minimal impact on survival and frequent relapses.
  • The study investigates new phenothiazine-based inhibitors targeting Tousled-like kinase-1 (TLK1), which is overexpressed in GBM and contributes to DNA repair, potentially enhancing the efficacy of TMZ.
  • Results show that the combination of phenothiazines with TMZ reduces tumor growth and invasion in MGMT-deficient cells, while also increasing DNA damage, suggesting TLK1 inhibitors could be a promising new treatment for GBM patients.
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Background: Establishing a new medical school is a significant venture involving many complex political, social, economic, educational, and organisational considerations. The published literature on the process of establishing a new medical school is, however, under-developed with minimal empirical research and no explicit reference to theory. This research sought to address these gaps and establish an empirical and theoretical evidence-base for the process of new medical school establishment in diverse contexts, particularly medically under-served areas.

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