Nowadays, several processes to enrich desired bioactive compounds in plant extracts have been developed. The objective of the present study was to assess the performance of bovine serum albumin in increasing the extractive yields of anthraquinones and diarylheptanoids from their respective raw plant powder extracts. Aloe emodin, rhein, emodin, and chrysophanol, from , , , and , and curcumin from were analyzed in parent dry extracts, solubilized either with water, ethanol, or hydro-alcoholic mixtures, and in ones treated with aqueous solutions of bovine serum albumin by HPLC with UV/Vis detection.
View Article and Find Full Text PDFStudy Design: Systematic Review Study.
Objectives: The objective of this study is to assess the cost-effectiveness and cost-utility of rhBMP-2 in spine surgeries.
Methods: PubMed, MEDLINE, OVID and CENTRAL (Cochrane Central Register of Controlled Trials) databases were systematically searched for studies reporting the use of rhBMP-2 for spinal procedures in comparison to autograft and/or allograft and alternative graft materials under consideration of cost-effectiveness, cost-benefit, cost minimization, and/or cost-utility analysis.
Pembrolizumab (Keytruda), an immune checkpoint inhibitor, has been increasingly utilized in the treatment of metastatic urothelial carcinoma. While offering a favorable safety profile compared to traditional chemotherapy, it presents unique risks, including immune-related adverse events (irAEs). This case report describes a 77-year-old woman with a history of invasive bladder cancer treated with pembrolizumab who developed severe bilateral ptosis, myositis, and myocarditis.
View Article and Find Full Text PDFInherited cardiac channelopathies are major causes of sudden cardiac death (SCD) in young people. Genetic testing is focused on the identification of single-nucleotide variants (SNVs) by Next-Generation Sequencing (NGS). However, genetically elusive cases can carry copy number variants (CNVs), which need specific detection tools.
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