Publications by authors named "S Kilaru"
Results of SurVeil Versus IN.PACT Admiral Paclitaxel Coated Balloons in Femoropopliteal Arteries: Outcomes of the Randomised TRANSCEND Study Through 24 Months.
Marianne Brodmann William A Gray Peter A Schneider Katharina Kurzmann-Guetl Leyla Schweiger Sashi Kilaru
Eur J Vasc Endovasc Surg
November 2024
Article Synopsis
- * In this randomized controlled trial involving 446 patients, the SurVeil PCB showed a primary safety rate of 91.8% and a primary efficacy rate of 82.2%, while the IN.PACT Admiral had rates of 89.8% and 85.9%, respectively.
- * The results indicate that the SurVeil PCB is a safe and effective treatment option, demonstrating non-inferiority to the IN.PACT Admiral PCB over a 24-month period.
Article Synopsis
- Understanding how pathogens like Zymoseptoria tritici defend against host-generated hydrogen peroxide (HO) is key to studying fungal infections.
- Our research focused on two catalase-peroxidase (CP) genes, ZtCpx1 and ZtCpx2, which help the fungus manage oxidative stress during infection.
- We found that ZtCpx1 is critical for the fungus's virulence and response to HO, while ZtCpx2 plays a supportive role; both genes together enhance the pathogen's ability to thrive in hostile environments.
New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms.
Biochim Biophys Acta Mol Cell Res
December 2024
Acyl-CoA binding domain-containing proteins (ACBDs) perform diverse but often uncharacterised functions linked to cellular lipid metabolism. Human ACBD4 and ACBD5 are closely related peroxisomal membrane proteins, involved in tethering of peroxisomes to the ER and capturing fatty acids for peroxisomal β-oxidation. ACBD5 deficiency causes neurological abnormalities including ataxia and white matter disease.
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