Publications by authors named "S Khongsti"
Stomach cancer is the fifth most common cancer in terms of prevalence and incidence and the fourth leading cause of mortality in men and women worldwide. It is well-established that aberrant DNA methylation in cells can lead to carcinogenesis. The primary objective of our study was to investigate the aberrant DNA methylation status of genes associated with stomach cancer with a particular reference to the ethnic population of Mizoram, North East India.
View Article and Find Full Text PDFBackground & Objectives: Oral squamous cell carcinoma is one of the most lethal forms of cancer, and its aetiology has been attributed to both genetic and epigenetic factors working in liaison to contribute to the disease. Epigenetic changes especially DNA methylation is involved in the activation or repression of gene functions. The aim of this study was to investigate the DNA methylation pattern and expression profiling of the promoter regions of FMS-related tyrosine kinase 3 (FLT3), erythrocyte membrane protein band 4.
View Article and Find Full Text PDFArticle Synopsis
- - Oral Squamous Cell Carcinoma (OSCC) is a common and aggressive type of cancer, and the study focuses on how DNA methylation, an epigenetic factor, is involved in its development, particularly in the ethnic population of Meghalaya, North East India.
- - Researchers identified over 27,000 specific DNA sites that showed different methylation patterns in oral cancer tissues compared to normal tissues, with 45 genes in the promoter region being particularly noteworthy.
- - Among these genes, 38 were hypermethylated (more methylation than normal), and 7 were hypomethylated (less methylation), with some genes overlapping with previous studies, suggesting potential new biomarkers for diagnosing OSCC.