Publications by authors named "S Khimake"
Additive effect of lithium and clonidine with 5-HT1A agonists in the forced swimming test.
Prog Neuropsychopharmacol Biol Psychiatry
March 1994
Article Synopsis
- The study aimed to explore the combination effects of lithium and clonidine with 5-HT1a agonists on depression-like behavior in mice using a forced swimming test.
- The anti-depressant effects of the 5-HT1a agonists were assessed, revealing that only the drug 8-OH-DPAT was effective in reducing immobility time when tested alone.
- When combined with lithium or clonidine, only the agonists gepirone and ipsapirone showed a significant reduction in immobility, suggesting that these substances could help identify antidepressant-like properties in new medications.