Non-Surgical Management of the Periorbital Area.

Non-surgical rejuvenation of the periorbital area is becoming increasingly popular given the downtime and risks associated with surgical procedures. Dermabrasion and chemical peels were first used along with neuromodulators and dermal fillers. Over the past few decades, laser treatments have emerged as the gold standard for periorbital skin resurfacing.

Application of Hard and Soft Tissue Regenerative Approach in Predictable Management of Peri-Implantitis: A Five-Year Follow-Up Case Report.

As implant dentistry expands, the number of implants being placed increases, and so does the prevalence of associated complications, resulting in implant failure if not timely attended. The present case report aims to discuss the successful regenerative management of peri-implantitis by both hard and soft tissue augmentation with a five-year follow-up. A 60-year-old male reported a chief complaint of purulent discharge, 7 mm peri-implant probing depth, and radiographic bone loss with no pathologic mobility of the dental implant.

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.

Ergothioneine (EGT) is a diet-derived, atypical amino acid that accumulates to high levels in human tissues. Reduced EGT levels have been linked to age-related disorders, including neurodegenerative and cardiovascular diseases, while EGT supplementation is protective in a broad range of disease and aging models in mice. Despite these promising data, the direct and physiologically relevant molecular target of EGT has remained elusive.