Publications by authors named "S Khedr"
Folic acid (FA), with its anti-inflammatory and antioxidant properties, may offer protection against ischemia-reperfusion (IR) injury. This study investigated whether FA safeguards rat kidneys from IR by targeting high mobility group box-1 (HMGB1), a key inflammatory mediator. Fifty adult male Wistar rats were randomly allocated into four groups: control, IR, IR + FA pretreatment, and FA alone.
View Article and Find Full Text PDFImpact of a New Preoperative Immune-Nutrition Protocol Using Zinc on Hospital Outcomes of Children with Hirschsprung's Disease: A Novel Randomized Controlled Trial.
Pediatr Gastroenterol Hepatol Nutr
January 2025
Purpose: Research proved the beneficial effect of Zinc on human health and Gastrointestinal tract inflammatory diseases. We propose that zinc would be of value in children with Hirschsprung's disease (HD) undergoing elective pull-through surgery. This study was carried out to determine the influence of preoperative zinc intake on postoperative outcomes, especially the hospital length of stay in patients diagnosed with HD as a primary outcome.
View Article and Find Full Text PDFOver the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for their wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, and drug/gene delivery. Among these, zinc oxide (ZnO) NPs stand out for their versatility and effectiveness.
View Article and Find Full Text PDFDiabetic kidney disease (DKD) is the leading cause of chronic renal pathology. Understanding the molecular underpinnings of DKD is critical to designing tailored therapeutic approaches. Here, we focused on sex differences and the contribution of aging toward the progression of DKD.
View Article and Find Full Text PDFArticle Synopsis
- c-Jun N-terminal kinases (JNKs), part of the MAPK family, are crucial for how cells react to stress and inflammation, and play a significant role in cancer development and progression.
- Abnormal activation of JNKs can lead to tumor growth, resistance to treatments, and influences the tumor microenvironment by regulating inflammation and immune responses.
- The review highlights both the complexity of JNK functions in cancer biology and the potential for developing targeted therapies, including promising JNK inhibitors, to enhance cancer treatment outcomes.