Publications by authors named "S Khanduja"
Article Synopsis
- - Sickle cell disease (SCD) is a hereditary blood disorder that leads to chronic pain, anemia, and various health complications, but advancements in treatments have improved patient outcomes over time.
- - Despite progress, challenges like limited access to stem cell transplants and complications from current therapies highlight the need for ongoing research in SCD treatments.
- - The recent FDA approval of Casgevy, a CRISPR/Cas9-based gene therapy, represents a significant step in SCD treatment, with the review focusing on its potential effectiveness and safety compared to traditional methods, emphasizing the need for long-term research.
Background: Early detection of acute brain injury (ABI) at the bedside is critical in improving survival for patients with extracorporeal membrane oxygenation (ECMO) support. We aimed to examine the safety of ultra-low-field (ULF; 0.064-T) portable magnetic resonance imaging (pMRI) in patients undergoing ECMO and to investigate the ABI frequency and types with ULF-pMRI.
View Article and Find Full Text PDFPrevalence and Neurological Outcomes of Comatose Patients With Extracorporeal Membrane Oxygenation.
J Cardiothorac Vasc Anesth
November 2024
Article Synopsis
- The study aimed to analyze the prevalence, risk factors, and in-hospital outcomes of patients in a coma who were on extracorporeal membrane oxygenation (ECMO) support in a tertiary hospital setting.
- Of the 230 adult patients studied, a significant portion achieved 24-hour off sedation, with coma rates being higher among those who were unable to remain off sedation compared to those who were.
- The findings indicated that coma is linked to poor discharge outcomes, especially in patients on venoarterial (VA) ECMO, with the need for renal replacement therapy identified as a key risk factor.
The mortality rate of Nipah virus (NiV) can vary in different regions, and its pattern across timelines has yet to be assessed. The primary objective is to perform a comparative analysis of mortality rates across different timelines and countries. Articles reporting NiV mortality from inception to November 2023 were analyzed in PubMed, Ovid Embase, Scopus, and Web of Science databases.
View Article and Find Full Text PDFAs therapies, oncolytic viruses regress tumors and have the potential to induce antitumor immune responses that clear hard-to-treat and late-stage cancers. Despite this promise, clearance from the blood prevents treatment of internal solid tumors. To address this issue, we developed virus-delivering Salmonella (VDS) to carry oncolytic viruses into cancer cells.
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