Publications by authors named "S Khalili"
Article Synopsis
- Pancreatic cancer presents challenges such as unusual symptoms, rapid progression, and a lack of reliable early diagnostic methods and effective treatments.
- Research indicates that exosomes (tiny vesicles secreted by cells) could play significant roles in diagnosing and treating pancreatic cancer, as they may serve as less invasive liquid biopsies and drug carriers.
- While current studies show promise for using exosomes in early diagnosis and monitoring, more research and clinical trials are needed before they can become standard tools for managing pancreatic cancer.
Acute Lymphoblastic Leukemia (ALL) is a heterogeneous blood cancer characterized by the uncontrolled growth of immature lymphoid cells due to dysregulated signaling pathways. It is the most common pediatric cancer, with high cure rates in children, but significantly lower survival rates in adults. Current theranostic strategies, including chemotherapy, immunotherapy, and nanomedicine, aim to improve detection and treatment precision but are limited by side effects, drug resistance, high costs, and stability issues.
View Article and Find Full Text PDFObjectives: Natural killer (NK) cells are the most professional innate immune cells that initiate extracellular apoptosis via cytotoxic granules in malignant cells. Antitumoral properties of NK-derived exosomes (Exos) are attributed to their parent cells. Loading drugs into Exos as a carrier can enhance their effect and enable targeted delivery.
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- Chronic inflammatory skin conditions like atopic dermatitis and psoriasis are challenging to treat with existing options, such as topical corticosteroids, which have limitations and side effects.
- Recent research highlights the potential of placental derivatives—from decidua, placental membrane, and umbilical cord—to effectively treat these conditions by reducing inflammation and promoting healing.
- The use of these derivatives may revolutionize care by providing benefits for not just psoriasis and atopic dermatitis, but also other skin diseases like vitiligo and pemphigus, potentially changing treatment methodologies and improving patient outcomes.
The increasing incidences of morbidity and mortality associated with cardiovascular diseases represent significant difficulties for clinical treatment and have a major impact on patient health. Wnt signaling pathways are highly conserved and are well known for their regulatory roles in embryonic development, tissue regeneration, and adult tissue homeostasis. Wnt signaling is classified into two distinct pathways: canonical Wnt/β-catenin signaling and noncanonical pathways, including planar cell polarity and Wnt/Ca2+ pathways.
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