Publications by authors named "S Kempf"

Article Synopsis
  • Fatty acid metabolites from cytochrome P450 enzymes and soluble epoxide hydrolase (sEH) play crucial roles in regulating inflammation, particularly through macrophage polarization.
  • * The study reveals that transforming growth factor β (TGF-β) triggers macrophages to adopt a pro-resolving phenotype by activating Alk5 and Smad2, which boosts sEH expression and activity.
  • * Macrophages lacking sEH showed poorer repolarization and phagocytosis, with findings indicating an autocrine feedback loop between sEH, its metabolite 11,12-EET, and TGF-β1 that influences macrophage behavior.*
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The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms regulating pericyte-endothelial cell communication remain unclear. This study investigated the formation and function of pericyte tunneling nanotubes (TNTs) and their impact on endothelial cell metabolism. TNTs were analyzed in vitro in retinas and co-cultures of pericytes and endothelial cells.

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The Radar for Europa Assessment and Sounding: Ocean to Near-surface (REASON) is a dual-frequency ice-penetrating radar (9 and 60 MHz) onboard the Europa Clipper mission. REASON is designed to probe Europa from exosphere to subsurface ocean, contributing the third dimension to observations of this enigmatic world. The hypotheses REASON will test are that (1) the ice shell of Europa hosts liquid water, (2) the ice shell overlies an ocean and is subject to tidal flexing, and (3) the exosphere, near-surface, ice shell, and ocean participate in material exchange essential to the habitability of this moon.

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The selected ice nanoparticle accelerator, SELINA, was used to prepare beams of single ice particles with positive or negative charge. Positively charged particles were prepared from deionized water and 0.05-0.

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The DESTINY(Demonstration and Experiment of Space Technology for INterplanetary voYage with Phaethon fLyby and dUst Science) Dust Analyser (DDA) is a state-of-the-art dust telescope for the analysis of cosmic dust particles. As the primary scientific payload of the DESTINY mission, it serves the purpose of characterizing the dust environment within the Earth-Moon system, investigating interplanetary and interstellar dust populations at 1 AU from the Sun and studying the dust cloud enveloping the asteroid (3200) Phaethon. DDA features a two-axis pointing platform for increasing the accessible fraction of the sky.

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