Publications by authors named "S Kellermann"
Life-threatening polytrauma results in early activation of the complement and apoptotic system, as well as leukocytes, ultimately leading to the clearance of damaged cells. However, little is known about interactions between the complement and apoptotic systems in PMN (polymorphonuclear neutrophils) after multiple injuries. PMN from polytrauma patients and healthy volunteers were obtained and assessed for apoptotic events along the post-traumatic time course.
View Article and Find Full Text PDFInitially underestimated as platelet dust, extracellular vesicles are continuously gaining interest in the field of inflammation. Various studies addressing inflammatory diseases have shown that microvesicles (MVs) originating from different cell types are systemic transport vehicles carrying distinct cargoes to modulate immune responses. In this study, we focused on the clinical setting of multiple trauma, which is characterized by activation and dysfunction of both, the fluid-phase and the cellular component of innate immunity.
View Article and Find Full Text PDFPZT-silsesquioxane-based 0-3 hybrid materials are prepared by mixing lead zirconate titanate (Pb(Zr,Ti)O; PZT) powder with a [R-SiO] (R = H, CH, CH=CH, CH) silsequioxane preceramic polymer. A PZT load up to 55 vol.% can be reached in the final composite.
View Article and Find Full Text PDFAfter severe trauma, the resulting excessive inflammatory response is countered by compensatory anti-inflammatory mechanisms. The systemic inflammatory response to trauma enhanced by inappropriately timed surgical second hits may be detrimental for the patient. On the other hand, overwhelming anti-inflammatory mechanisms may put patients at increased risk from secondary local and systemic infections.
View Article and Find Full Text PDFArticle Synopsis
- Out-of-pocket healthcare costs force many poor individuals into poverty, hindering efforts for universal healthcare as outlined by the World Health Organization.
- Community-based health insurance (CBHI) has been shown to enhance healthcare access by mitigating financial risks, leading to lower under-5 mortality rates.
- A study of the eQuality Health Bwindi CBHI scheme in Uganda revealed that having health insurance significantly reduced child mortality and increased the likelihood of receiving healthcare services, demonstrating the benefits of CBHI in rural areas.