Publications by authors named "S Keir"
Communities face a mounting social, economic and health burden as the global population of older adults continues to grow. Regular physical activity is consistently reported as an effective means of maintaining health and independence in older adults, yet engagement in activity remains low. This study assesses the activity levels of adults aged over 65 years residing in Australian assisted living homes, and extended to examine their perception of their activity and explore possible factors that hinder or promote their engagement in physical activity.
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- The study addresses a key challenge in treating glioblastoma (GBM) by using a new device that offers continuous access to tumors, improving our understanding of tumor progression and treatment responses.
- Researchers tested an aligned nanofiber device in rodent models and found it to be safe, providing ample high-quality samples for genomic analyses and allowing for the study of tumor behavior over time.
- The findings suggest that this device could become a valuable tool for monitoring GBM and tailoring clinical treatments based on real-time data from the tumor environment.
Identification of immunogenic cancer neoantigens as targets for therapy is challenging. Here, we integrate the whole-genome and long-read transcript sequencing of cancers to identify the collection of neo-open reading frame peptides (NOP) expressed in tumors. We termed this collection of NOPs the tumor framome.
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- Researchers are investigating how stimulating the innate immune system could help treat gliomas, especially focusing on the interaction between ATRX mutations and IDH mutations.
- ATRX-deficient glioma models show increased sensitivity to dsRNA treatments, leading to reduced tumor lethality and higher T-cell infiltration, but IDH1 mutations negatively affect immune gene expression.
- IDH1 doesn't prevent the sensitivity to dsRNA, but it does diminish the immune response, suggesting that targeting innate immunity could be a promising therapeutic strategy for astrocytomas.
Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the stemness and suppressed the propagation of primary BTIC cultures bearing amplification. These effects on BTICs were accompanied by altered gene expression profiling indicative of their more differentiated states, resonating with the activity of clemastine in promoting the differentiation of normal oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes.
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