Publications by authors named "S Keil"
Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue and tenderness and closely associated with high levels of stress. FMS is therefore often considered a stress-related disease. A comparative study was conducted with 99 individuals diagnosed with FMS and a control group of 50 pain-free individuals.
View Article and Find Full Text PDFEmbryonic development is orchestrated by the action of morphogens, which spread out from a local source and activate, in a field of target cells, different cellular programs based on their concentration gradient. Fibroblast growth factor 8 (Fgf8) is a morphogen with important functions in embryonic organizing centers. It forms a gradient in the extracellular space by free diffusion, interaction with the extracellular matrix (ECM), and receptor-mediated endocytosis.
View Article and Find Full Text PDFArticle Synopsis
- - Collective cell migration is important for processes like development, healing, and cancer spread, and in the study of Drosophila, border cells (BCs) migrate with the help of a kinase called Misshapen (Msn).
- - The protein Tao serves as an important activator of Msn in border cells; reducing Tao levels hinders BC migration, mimicking the effects of a loss of Msn function.
- - Msn's distribution is influenced by its interaction with a protein called Rap2l, which assists in transporting Msn to the endolysosomal pathway for degradation; this process is critical for maintaining balanced Msn levels and activity in BCs.