Publications by authors named "S Kawakatsu"
Article Synopsis
- The study investigates the genetic heterogeneity and molecular profiles of bile tract cancer (BTC) using whole-genome sequencing to identify actionable gene mutations involved in its progression and treatment resistance.
- The analysis of six BTC samples revealed a high average of somatic mutations with a significant prevalence of single nucleotide variants (SNVs), but no matching mutations were found in the existing cancer database.
- Key findings suggest that samples without vascular invasion had a higher mutation prevalence, highlighting specific genes like ADAMTS7, AHNAK2, and CAPN10 that show differences in mutation rates between groups, emphasizing the complexity and genetic diversity of BTC.
Background: A histologically involved surgical margin (R1) is often observed after resection for cholangiocarcinoma. Compared with a negative margin (R0), R1 with invasive carcinoma (R1inv) markedly worsens survival, whereas the prognostic effect of R1 with carcinoma in situ (R1cis) remains controversial.
Methods: Patients who underwent resection for perihilar cholangiocarcinoma between 2002 and 2019 were retrospectively reviewed.
A 21-year-old man was diagnosed with segmental adenomyomatosis of the gallbladder based on ultrasonography and computed tomography images. Computed tomography with drip infusion cholangiography revealed that the cystic duct joined the infraportal type of the left lateral bile duct (IPLLBD), which runs caudal to the umbilical portion, and that the left medial bile duct joined the right hepatic duct without forming the left hepatic duct. We planned a single-incision laparoscopic cholecystectomy with fluorescent cholangiography.
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- The study aimed to determine if preoperative autologous blood donation helps lower the risk of post-hepatectomy liver failure (PHLF) in patients with perihilar malignancy undergoing major liver surgery.
- Conducted as a randomized clinical trial, 138 patients were assigned to either receive autologous blood transfusions or not during their surgeries, with primary focus on post-operative PHLF rates.
- Results showed no significant differences in PHLF incidence or other surgery-related outcomes between the two groups, indicating that autologous blood storage did not effectively reduce PHLF risk.
Background And Aims: Mild cognitive impairment (MCI) is a widespread condition in older individuals, posing significant risk of dementia. However, limited research has been conducted to explore effective interventions and clarify their impact at the neural level. Therefore, this study aimed to investigate the effects of computerized cognitive training (CCT) and explore the associated neural mechanisms in preventing dementia in older individuals with MCI, with a view to inform future intervention efforts.
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