Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir.

With the aim to improve and extend the antiviral activity of the antiherpic drug penciclovir, to a wider spectrum of viruses, we have synthesized and characterized new binary and ternary complexes of Pd(II) of formulae cis-(pen)(2)PdCl(2) and cis,[(nucl)(2)Pd(pen)(2)]Cl(2), where nucl = guanosine, inosine, cytidine or penciclovir. The characterization was mainly based on IR and (1)H NMR spectroscopy, and the results showed that in all prepared complexes, penciclovir coordinates to the metal through N7. The far-i.