Development of pH sensitive microparticles of Karaya gum: By response surface methodology.

The objective of the proposed work was to prepare pH sensitive microparticles (MP) of Karaya gum using distilled water as a solvent by spray drying technique. Different formulations were designed, prepared and evaluated by employing response surface methodology and optimal design of experiment technique using Design Expert(®) ver 8.0.

Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent.

A key difference between normal and malignant prostate cells in vitro and in vivo is that both alleles of PTEN are largely intact in normal benign prostate glands and cultured epithelial cells, whereas one or both alleles of PTEN are mutant or deleted in the majority of prostate tumors and malignant prostate cancer cell lines. Intact PTEN suppresses phosphorylation of Akt downstream of PI3K activation in non-transformed cells whereas Akt phosphorylation is unimpeded in malignant cells that are often PTEN-deficient. We have previously shown that activation of the CXCL12/CXCR4 axis transactivates the EGFR to promote pro-proliferative signaling preferentially through the Raf/MEK/Erk pathway in benign prostate epithelial cells.

To Evaluate the Bone Mineral Density in Mandible of Edentulous Patients using Computed Tomography: An In Vivo Study.

Background: To evaluate the bone mineral density in the mandible of edentulous patients at prospective intraoral implant sites. Pre-operative evaluation of bone density is essential to assist the clinician with the treatment planning of implant supported prosthesis.

Materials And Methods: A study group of 12 edentulous subjects comprising of six male and six female between the age group of 45-55 years seeking implant supported prosthesis were selected.

To evaluate and compare the porosities in the acrylic mandibular denture bases processed by two different polymerization techniques, using two different brands of commercially available denture base resins - an in vitro study.

Background: The aim of this study was to evaluate and compare the porosities in the mandibular acrylic denture bases processed by heat and microwave polymerization techniques, using two different brands of commercially available denture base resins.

Materials & Methods: Two brands of heat activated denture base resins, DPI plain and Acralyn H cross linked denture base resins designed for conventional water bath polymerization, were used to prepare 48 test specimens of mandibular acrylic denture bases. The test specimens were processed using one cycle of conventional water bath polymerization and one cycle of microwave polymerization.