Publications by authors named "S Kashani"
In this work, Oxford Nanopore sequencing is tested as an accessible method for quantifying heterogeneity of amplified DNA. This method enables rapid quantification of deletions, insertions, and substitutions, the probability of each mutation error, and their locations in the replicated sequences. Amplification techniques tested were conventional polymerase chain reaction (PCR) with varying levels of polymerase fidelity (OneTaq, Phusion, and Q5) as well as rolling circle amplification (RCA) with Phi29 polymerase.
View Article and Find Full Text PDFCleavable side chain based conjugated polymers (CSCPs) represent a unique approach to offering solution processability with added benefits via the elimination of insulating side chains. This work highlights an optimally designed polythiophene-carboxylic acid based CSCP, POET-T2-COOH, which achieves a conductivity exceeding 350 S/cm in molecularly doped and side chain cleaved films, 100-100,000 times higher than three other structurally isomeric CSCPs. The high conductivity of POET-T2-COOH is accomplished via a new "cleavage with doping" methodology, synergistically combining a strong acid and a primary dopant.
View Article and Find Full Text PDFBackground: Multiple studies have investigated the serum concentrations of calcium (Ca) and magnesium (Mg) in preeclampsia, but the results have been contradictory. The objective of this systematic review and meta-analysis was to examine the association between serum calcium and magnesium levels in patients with preeclampsia and those in the healthy pregnancies.
Materials And Methods: A comprehensive search was conducted in various online databases, including PubMed/Medline, Scopus, Embase, Web of Sciences, and Cochrane library to identify relevant studies on Ca and Mg levels in preeclampsia up to July 2023.
Article Synopsis
- Neuropathic pain (NP) is a challenging condition that can occur after spinal cord injury (SCI), and this study investigates the brain area called the periaqueductal gray (PAG) and how it relates to NP development using resting-state functional MRI (rsfMRI).
- The research involved 20 participants: 10 SCI patients (with and without NP) and 10 healthy controls, examining differences in functional connectivity (FC) between the PAG and other brain regions.
- Findings revealed decreased FC in SCI patients with NP compared to healthy controls and increased FC in other areas when compared to SCI patients without NP, suggesting significant brain connectivity alterations linked to neuropathic pain after spinal cord injury.
Introduction: Complicated field extrication may require the assistance of a surgical team to perform an on-scene limb amputation. Although a rare event, when needed, an organized and efficient response is critical to successful outcomes.
Methods: The Los Angeles County Hospital Emergency Response Team (HERT) program and the organization of the team is described, and a multidisciplinary quality improvement process reviewed and analyzed two cases and identified areas for performance improvement.