Antiprotozoal activity of natural products from Nigerien plants used in folk medicine.

In the course of the screening of plants from Niger for antiprotozoal activity, the methanol extract of , and the dichloromethane extracts of and were found to be active against protozoan parasites, namely , , and/or . Myricitrin (), quercitrin () and 1-palmitoyl-lysolecithin () were isolated from . From , the three triterpene derivatives , , and are described here for the first time.

Antiproliferative activity of compounds isolated from the root bark of Lannea acida in multiple myeloma cell lines.

Lannea acida A. Rich. is a native plant of West Africa used in traditional medicine against diarrhea, dysentery, rheumatism, and women infertility.

Isolation and Structure Elucidation of Compounds from and Their Antiproliferative Activity against Multiple Myeloma Cells.

The phytochemical investigation of the dichloromethane root extract of led to the isolation of 18 compounds. Among these, compounds -, defined as 9-hydroxy-2,2-dimethyl-2-benzo[]chromene-5,10-dione 6--β-d-glucopyranoside (), (2,3)-3,4,7-trihydroxy-2-(3'-methylbut-2'-en-1'-yl)-2,3-dihydro-1-inden-1-one (), ()-2-(1',4'-dihydroxy-4'-methylpent-2'-en-1'-ylidene)-4,7-dihydroxy-1-indene-1,3(2)-dione (), ()-2,5,8-trihydroxy-3-(2'-hydroxy-3'-methylbut-3'-en-1'-yl)naphthalene-1,4-dione (), 6-hydroxy-3-(3'-methylbut-2'-en-1'-yl)-4-oxo-4-chromene-5-carboxylic acid (), and ()-2-(1'-hydroxy-4'-methylpent-3'-en-1'-yl)anthracene-9,10-dione (), respectively, have not yet been described. Their structures were elucidated based on spectroscopic data analysis, including IR, NMR, HRESIMS and ECD measurements.

Phytochemical Investigation of the Roots of and Antiproliferative Activity of the Isolated Compounds against Multiple Myeloma Cells.

is a herbaceous plant belonging to the family Convolvulaceae and is native to tropical regions of Africa, America, and Asia. A dichloromethane root extract showed antiproliferative activity against multiple myeloma cells (RPMI 8226). The phytochemical investigation led to the isolation of 15 compounds.

Pyridine-4(1)-one Alkaloids from as Antitrypanosomatid Agents.

Twelve new pyridine-4(1)-one derivatives, namely, 8-demethoxywaltherione F (), waltheriones R-V (, , , , and ), 1-methoxywaltherione O (), ()-15-hydroxywaltherione G (), (8)-8-hydroxywaltherione M (), (9,13)-2-hydroxymethylwaltherione C (), (9,10,13)-10-hydroxywaltherione C (), and ()-13-methoxywaltherione V (), as well as melovinone () and 5'-methoxywaltherione A () were isolated from the CHCl extract of the aerial parts of Their chemical structures were determined by means of a comprehensive analysis including H NMR, DEPTQ, HSQC, HMBC, H-H COSY, ROESY, and HRESIMS data. The absolute configurations were assigned via comparison of the experimental and calculated ECD data. In addition, the isolated constituents as well as the known waltheriones M-Q were evaluated for their in vitro antitrypanosomal activity.