Synthesis of diversely substituted quinazoline-2,4(1,3)-diones by cyclization of -butyl (2-cyanoaryl)carbamates.

The synthesis of diversely substituted quinazoline-2,4(1,3)-diones by cyclization of -butyl (2-cyanoaryl)carbamates using readily accessible Boc protected -amino nitriles is reported. The reaction proceeds smoothly at room temperature using 1 equiv. of HO under basic conditions.

The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site.

 Wound healing is a dynamic and complex process. Therefore, no single agent can efficiently mediate all aspects of the wound healing process. Split-thickness graft has become a workhorse of plastic surgery for wound or raw area cover.

Escobar Syndrome with Monodactyly: A Rare Case Report.

Escobar syndrome (nonlethal type of multiple pterygium syndrome) is a very rare genetic disorder. The central manifestations of Escobar syndrome are the presence of multiple pterygia, fixed joint contractures, and characteristic facies. Here, we report a case of Escobar syndrome with additional features such as monodactyly and hypoplastic pectoralis muscle.

Regioselective -Silyllithiation of Propargylic Alcohols.

Among the known hydrosilylation or carbosilylation conditions of alkynes, -addition of the two units across the triple bond is considered rare compared to the counterpart. For -silylative vicinal difunctionalizations, transition-metal catalysts, such as ruthenium or palladium complexes, are generally required. Accordingly, silyl alkali metals have not been employed for those -addition transformations.

Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial.

Background: To compare the efficacy and safety of combination of curcuminoid complex and diclofenac vs diclofenac alone in the treatment of knee osteoarthritis (OA).

Methods: In this randomized trial, 140 patients of knee OA received either curcuminoid complex 500 mg (BCM-95) with diclofenac 50 mg 2 times daily or diclofenac 50 mg alone 2 times daily for 28 days. Patients were assessed at baseline, day 14 and day 28.