Sero-Surveillance to Evaluate Trends in the Transmission of SARS-CoV-2 in a Central Indian District.

Background and objective The actual community burden of SARS-CoV-2 is undervalued, as the estimates are just the symptomatic infections. The acute phase of the pandemic has waned, and the analytical comparison of infection spread through repeated sero-epidemiological studies is important in the formulation of effective public health strategies. This study investigated the level of seroprevalence of IgG antibodies for the SARS-CoV-2 virus in the Nagpur district, Maharashtra, India.

Association between smartphone addiction and sedentary behaviour amongst children, adolescents and young adults: A Systematic Review and meta-analysis.

Background: The rapid proliferation of smartphones has raised concerns about their impact on physical activity levels, particularly among younger demographics. While smartphones offer numerous benefits, there is growing evidence to suggest that excessive use may lead to sedentary behaviours, potentially impacting physical health adversely. Hence, this review was done to explore the association between smartphone addiction and reduced physical activity amongst children, adolescents and young adults.

The role of molecular biomarkers in the diagnosis, prognosis, and treatment stratification of oral squamous cell carcinoma: A comprehensive review.

One of the most common cancers targeting the area of the head and neck is oral squamous cell carcinoma (OSCC), carrying a heavy global health cost. With a high incidence of metastasis and recurrence, the outlook for OSCC remains dismal despite advancements in treatment. This has sparked an investigation into molecular biomarkers, which have the potential to improve early diagnosis, forecast patient outcomes, and direct therapeutic approaches.

Thyrotoxicosis With Medullary Thyroid Carcinoma: A Rare Endocrine Diagnostic Challenge.

The incidence of a hyper-functioning thyroid gland presenting alongside an underlying malignancy rarely occurs. Herein, we present a rare case of a 56-year-old female patient presenting with features of hyperthyroidism only to be later diagnosed with an underlying malignancy, medullary thyroid carcinoma (MTC). Ultrasonography (USG) of the neck revealed a suspicious nodule with microcalcifications in the right lobe of the thyroid.

Development of a syringe-hosted load-and-read immunoassay device using autoinjected distance readout in paper inserts.

Pressure-based signal readout is promising for developing instrument-free immunoassays, but new detection methods are desirable to further advance the applicability of point-of-care testing (POCT). Herein, we developed a syringe-hosted load-and-read immunoassay device using autoinjected distance readout in paper inserts. The device was composed of multiple disposable syringes as the host for immuno-recognition, a three-dimensional (3D)-printed loading magazine of the syringes, and paper inserts to the magazine for distance signal readout.