Publications by authors named "S Kanchi"

Diabetes has become a global epidemic, affecting even the younger people on an alarming scale. Inhibiting intestinal α-glucosidase is one of the key approaches to managing type 2 diabetes (T2D). In the present study, phenolic compounds (PCs) produced by endophytic fungi as potential α-glucosidase inhibitors (AGIs) are explored through ADMET profiling, molecular docking, and molecular dynamics (MD) Simulations.

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  • This study presents a method for creating a 3D nanocomposite of BiOI, ZnO, and carbon nanofibers on a nickel foam substrate through a hydrothermal process.
  • The resulting material showed impressive specific capacitance of 1073 F/g at a current density of 1 A/g and maintained 88.6% of its original capacity after 5000 charge-discharge cycles in a potassium hydroxide solution.
  • These results underscore the potential of 3D nanomaterials as effective electrode materials for advanced supercapacitor applications due to their superior energy storage characteristics.
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Background And Purpose: Epilepsy is a common and heterogenous neurological disorder characterized by recurrent spontaneous seizures. Animal models like rats play a crucial role in finding of mechanism of epilepsy in different brain regions. i.

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  • * The key reaction involved is a 1,3-dipolar cycloaddition which produces spiroquinoxalinopyrrolidine-chromanone hybrids with several bond formations and stereogenic centers.
  • * The newly created compounds exhibit strong inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with fluorinated variants showing the most potency, indicating their potential as effective inhibitors compared to standard drugs through both experimental and computational
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Protein engineering by directed evolution is time-consuming. Hence, in silico techniques like FoldX-Yasara for ∆∆G calculation, and SNPeffect for predicting propensity for aggregation, amyloid formation, and chaperone binding are employed to design proteins. Here, we used in silico techniques to engineer BDNF-NTF3 interaction and validated it using mutations with known functional implications for NGF dimer.

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