[Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan].

This paper reports results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan. The study included 16312 patients examined in different cities during 2011-2012. It showed that ascoril expectorant (Glenmark) at a standard dose is an effective agent for the treatment of cough in children above 3 years and adults aged up to 78 years with ARVI and acute bronchitis, exacerbation of these conditions or grade I-II chronic obstructire pulmonary disease.

Cytisin amidophosphate--the new cytoprotector.

This article describes the results of a clinical study of O,O dimethyl-N-cytinizylphosphate in healthy volunteers and 142 patients with the verified diagnosis of acute toxic hepatitis. The tolerability was good. The efficiency of the drug is considered to be very high, normalization of the state took less time in comparison with standard treatment; a significant improvement was achieved immediately after the first injection.

[The characteristics of gentamycin distribution when administered endolymphatically in an experiment].

Gentamicin distribution in some tissues of the abdominal cavity one hour after the intralymphovasal and intranodular administration to 32 rabbits was studied. The experiments were performed under conditions of the blocking and external drainage of the thoracic lymphatic duct. It was found that the optimal bacteriostatic concentrations were reached at both intralymphovasal and intranodular administration.

[Monomycin distribution in the tissues of animals of various ages].

The distribution of monomycin (15 mg/kg intramuscularly) in the blood serum and organs of mature, old and young rats was studied in the agar diffusion test. Bact. pumelis was used as test microorganism.

[Influence of halidor on experimental bronchospasm].

Through local stimulation of various structures of medulla oblongata a centrogenic bronchial spasm was simulated in acute tests on cats. A peripheral bronchial spasm was reporduced by stimulating the peripheral length of the vagus. An experimental bronchial spasm caused by activation of reticular nuclei and of a single fascicular nucleus halidor suppressed with doses half as large as the ones needed to inhibit the peripheral spasm.