Drug Development.

Background: The increased incidence of Alzheimer's disease (AD) rate represent an unmet medical need and thus critical for the development of novel molecular therapeutics. Recent work focusing on patients with apoE4 alleles has highlighted the association of brain cholesterol dysregulation with elevated pathological burden and neurodegeneration. These studies have highlighted the importance of the nuclear receptor Liver X receptor (LXR) for developing AD therapies.

Dementia Care Research and Psychosocial Factors.

Background: Exercise or cognitive interventions have already been sufficiently provided to the elderly, and their effectiveness has been proven. However, interventions in the context of promoting social interaction have not been well-implemented for the elderly, and few studies have considered the effectiveness of interaction mediation for the elderly. This study therefore sought to examine the effectiveness of interactive interventions by examining studies that provide interventions focusing on social interactions.

Value of the combination of intraepithelial tumor-infiltrating lymphocyte density and the heterogeneity of density as a prognostic marker in stage III colorectal cancers.

Tumor-infiltrating lymphocyte (TIL) density is both a prognostic and a predictive factor in colorectal cancer (CRC). Whether the heterogeneity of TIL density across the tumor plays an important role in the clinical outcome of CRC is not well known. Adjuvant chemotherapy-treated patients with stage III CRC were analyzed for survival according to TIL density and density heterogeneity, which were determined on CD8-immunostained slides using a machine learning method and by calculating the Simpson evenness index, respectively.

A 0.73 dB Multi-Gain Low Noise Amplifier Design with Fast Mode-Switching for 5G/4G Applications.

In this paper, a sub-1dB Low Noise Amplifier (LNA) with several gain modes, including amplification and attenuation modes required for the fifth and fourth generations (5G/4G) of mobile network applications, is proposed. Its current consumption is adaptive for every gain mode and varies to lower currents for lower amplifications due to the importance of current consumption for mobile network applications. The proposed LNA features an innovative architecture with a three-core input structure supporting multi-gain modes, achieving high gain and ultra-low noise performance.

Application of Transverse Process Hooks at Distal Thoracic Vertebrae in Uppermost Vertebral Instrumentation for Adult Spinal Deformity Surgery: Special Focus on Delayed-Onset Neurologic Deficits.

Objective: We aimed to investigate the incidence of delayed-onset neurological deficits (DONDs), DOND-related reoperation rates following adult spinal deformity (ASD) surgery, and efficacy of transverse process hooks (TPHs) at the uppermost instrumented vertebra (UIV) compared to pedicle screws (PSs).

Methods: We included 90 consecutive patients who underwent instrumented fusion from the sacrum to the distal thoracic spine for ASD, with a minimum follow-up of 24 months. Clinical and radiological outcomes were compared between 33 patients in the TPH group and 57 patients in the PS group, using the Scoliosis Research Society-22 Outcomes questionnaire (SRS-22), Medical Outcomes Study Questionnaire Short-Form 36 (SF-36), and various spinal sagittal parameters.