Publications by authors named "S K Yachha"
Timely diagnosis and management of pediatric acute liver failure (PALF) is of paramount importance to improve survival. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition invited national and international experts to identify and review important management and research questions. These covered the definition, age appropriate stepwise workup for the etiology, non-invasive diagnosis and management of cerebral edema, prognostic scores, criteria for listing for liver transplantation (LT) and bridging therapies in PALF.
View Article and Find Full Text PDFObjective: Biomarkers with high accuracy for identification of infection in decompensated chronic liver disease (DCLD) are urgently needed. We compared the accuracy of neutrophilic cluster of differentiation 64 (nCD64) with procalcitonin for diagnosis of bacterial infection in children with DCLD.
Methods: Consecutive children admitted with DCLD were enrolled prospectively.
Article Synopsis
- Hepatic encephalopathy (HE) is common in children with chronic liver disease (CLD), affecting about 31.2% of those studied, with identifiable causes in 90% of cases.
- The study involved daily monitoring of 160 children, revealing that infections and electrolyte imbalances were the most frequent precipitants of HE episodes.
- Patients with HE experienced worse overall health outcomes, including higher mortality rates during hospitalization and one month after discharge compared to those without HE.
Discrimination of pediatric cryptogenic multifocal ulcerous stenosing enteritis from small bowel Crohn's disease and gastrointestinal tuberculosis: A retrospective study (with videos).
Indian J Gastroenterol
December 2024
Article Synopsis
- Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare condition in children that presents similarly to inflammatory strictures of the small intestine, making it essential to differentiate it from Crohn's disease and gastrointestinal tuberculosis.
- Of the 48 cases analyzed, 13 were diagnosed with CMUSE, showing significant differences in clinical presentation and laboratory results compared to cases of Crohn's disease and tuberculosis, particularly the absence of elevated C-reactive protein (CRP) in CMUSE patients.
- The study highlighted distinct endoscopic findings among the conditions and noted varying effectiveness of treatment approaches, especially with relapses observed in patients receiving upfront immunosuppression after surgery.
Background: Acute hepatitis due to various tropical infections can mimic the clinical picture of acute viral hepatitis(AVH), leading to increased morbidity and mortality. We aimed to identify clinical and laboratory parameters that could help to distinguish acute hepatitis due to tropical infections from AVH.
Methods: We retrospectively analyzed our database of 150 children (107 boys) with AVH and 50 children(34 boys)with acute hepatitis due to tropical infections between January 2013 and March 2023.