Optimisation strategies for directed evolution without sequencing.

Directed evolution can enable engineering of biological systems with minimal knowledge of their underlying sequence-to-function relationships. A typical directed evolution process consists of iterative rounds of mutagenesis and selection that are designed to steer changes in a biological system (e.g.

Computational Synthetic Biology Enabled through JAX: A Showcase.

Mathematical modeling is indispensable in synthetic biology but remains underutilized. Tackling problems, from optimizing gene networks to simulating intracellular dynamics, can be facilitated by the ever-growing body of modeling approaches, be they mechanistic, stochastic, data-driven, or AI-enabled. Thanks to progress in the AI community, robust frameworks have emerged to enable researchers to access complex computational hardware and compilation.

The Luck of the Draw: Wellcome's Institutional Fund for Research Culture.

Wellcome's Institutional Fund for Research Culture (IFRC) closed call is an invite-only grant call in 2023. It is a departure from Wellcome's previous methods of institutional funding, providing institutions with up to £1m of grant funding to take on ambitious projects that advance research cultures and research environments that are equitable, diverse and supportive. Recognising the broad range of topics and ideas for advancing positive research cultures, IFRC is the first ever Wellcome-funding scheme to use partial randomisation to allocate funding.