Publications by authors named "S K Tigas"
Article Synopsis
- - Monogenic defects of beta cell function cause early-onset diabetes due to mutations in single genes that impact insulin secretion, representing about 5% of pediatric diabetes cases.
- - Over 40 subtypes of monogenic diabetes exist, including frequent types like MODY, and despite being linked to one gene mutation, the clinical symptoms can vary widely, complicating diagnosis.
- - Recent advances in genetic sequencing have improved the diagnosis of monogenic diabetes, which is crucial for appropriate treatment and genetic counseling, as the review aims to illustrate with hypothetical clinical scenarios.
Retrotransposons are invasive genetic elements, which replicate by copying and pasting themselves throughout the genome in a process called retrotransposition. The most abundant retrotransposons by number in the human genome are Alu and LINE-1 elements, which comprise approximately 40% of the human genome. The ability of retrotransposons to expand and colonize eukaryotic genomes has rendered them evolutionarily successful and is responsible for creating genetic alterations leading to significant impacts on their hosts.
View Article and Find Full Text PDFArticle Synopsis
- * The research involved 73 adult PwT1D patients, measuring various factors such as body weight, BMI, and glycaemic indices using continuous glucose monitoring (CGM).
- * Results showed no significant differences in glycaemic control between normal weight, overweight, and obese patients, but a healthy body weight was still linked to better overall glycaemic management.
Diabetes and dyslipidemia are common in patients with psychosis and may be related to adverse effects of antipsychotic medications. Metabolic disturbances in first-episode patients with psychosis are common, even prior to any antipsychotic treatment, and antipsychotic medications are implicated in the development of metabolic syndrome, at least in the long run. We therefore aimed to follow a group of drug-naïve, first-episode patients with psychosis at different time points (baseline, six months, and 36 months after the initiation of antipsychotic treatment) in order to evaluate the progression of metabolic abnormalities after antipsychotic therapy and the time-course of their onset.
View Article and Find Full Text PDFErgophysiological evaluation of heart failure patients with reduced ejection fraction undergoing exercise-based cardiac rehabilitation: A systematic review and meta-analysis.
Hellenic J Cardiol
June 2024
Background: This systematic review and meta-analysis aims to explore in heart failure (HF) patients with reduced ejection fraction (EF) undergoing exercise-based cardiac rehabilitation the following: 1) the comparison of temporal changes between peak oxygen uptake (VO2peak) and first ventilatory threshold (VO2VT1), 2) the association of VO2peak and VO2VT1 changes with physiological factors, and 3) the differential effects of continuous aerobic exercise (CAE) and interval training (IT) on VO2peak and VO2VT1.
Methods: A systematic literature search was conducted in PubMed, CENTRAL, and Scopus. Inclusion criteria were 1) original research articles using exercise-based cardiac rehabilitation, 2) stable HF patients with reduced EF, 3) available values of VO2peak and VO2VT1 (in mL/kg/min) both at baseline and after exercise training with comparison between these time points.