[The quantitative evaluation of mutation V617F of gene JAK2 under chronic myeloproliferative diseases].

The mutation V617F of gene JAK2 is detected in 95% of patients with genuine polycythemia, in 50% of patients with essential thrombocytemia and idiopathic myelofibrosis. The mutation V617F can be applied as a molecular marker of response to treatment in patients with chronic myeloproliferative diseases associated with this mutation. The technique of quantitative evaluation of V617F (sensitivity up to 0.

[An analysis of the possible mechanism of the ulcerostatic action of 1-ethoxysilatrane].

Stimulating effect of 1-ethoxysilatrane on healing processes of experimental stomach ulcers was studied in rats. 1-ethoxysilatrane inhibited lipid peroxidation in blood and stomach wall tissues, interacted with artificial membranes, and affected the rate of mitochondrial respiration in liver. A hypothesis is put forward on the membranotropic effect of 1-ethoxysilatrane which underlies its ulcerostatic effect.

[Possible mechanisms of anti-ulcer action of silatranes].

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

[1-Ethoxysilatrane: ulcerostatic effect and its possible mechanisms].

Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria.