Differentially expressed miRNA profiles of serum derived extracellular vesicles from patients with acute ischemic stroke.

Background: MicroRNAs (miRNAs) participate in diverse cellular changes following acute ischemic stroke (AIS). Circulating miRNAs, stabilized and delivered to target cells via extracellular vesicles (EVs), are potential biomarkers to facilitate diagnosis, prognosis, and therapeutic modulation. We aimed to identify distinctive expression patterns of circulating EV-miRNAs in AIS patients.

Influence of heating temperature and time on mechanical-degradation, microstructures and corrosion performances of Teflon/granite coated aluminum alloys used for non-stick cookware.

This study explores the functional characteristics (erosion, corrosion, mechanical damage, and microstructural features) of non-stick cookware made from aluminum alloys. Typically coated with polytetrafluoroethylene (PTFE-Teflon) or ceramic for non-stick properties, we conducted a systematic investigation using corrosion, abrasion, and mechanical tests on six types of cookware from different manufacturers (Manuf-1-6). The cookware was heated at various temperatures [Room temperature (RT), 100, 175, 250, & 350 °C] and times (45 & 120 min).

Conserved B cell signaling, activation, and differentiation in porcine jejunal and ileal Peyer's patches despite distinct immune landscapes.

Peyer's patches (PPs) are B cell-rich sites of intestinal immune induction, yet PP-associated B cell signaling, activation, and differentiation are poorly defined. Single-cell and spatial transcriptomics were completed to study B cells from porcine jejunum and ileum containing PPs. Intestinal locations had distinct immune landscapes, including more follicular B cells in ileum and increased MHC-II-encoding gene expression in jejunal B cells.

Date palm transcriptome analysis provides new insights on changes in response to high salt stress of colonized roots with the endophytic fungus .

Salinity is a significant threat that causes considerable yield losses in date palm. The root endophytic fungus has proven effective in providing salt stress tolerance to host plants. However, the underlying molecular mechanism facilitating the date palm's response to inoculation, and its involvement in the salt stress tolerance, remains unknown.

Voices of care: unveiling patient journeys in primary care for hypertension and diabetes management in Kerala, India.

Background: Diabetes and hypertension are leading public health problems, particularly affecting low- and middle-income countries, with considerable variations in the care continuum between different age, socio-economic, and rural and urban groups. In this qualitative study, examining the factors affecting access to healthcare in Kerala, we aim to explore the healthcare-seeking pathways of people living with diabetes and hypertension.

Methods: We conducted 20 semi-structured interviews and one focus group discussion (FGD) on a purposive sample of people living with diabetes and hypertension.