Publications by authors named "S K Sanghi"

Conversion of caustic red mud (RM, Alumina industry waste) into building materials becoming one of the viable solution for its large scale utilization. The building materials developed using RM often results in efflorescence due to its high alkalinity, which is detrimental for the structural integrity of the buildings. The X-ray shielding tiles developed through ceramic route using the mixtures of RM, BaSO and kaolin clay also suffers from severe NaSO efflorescence when sintered above 1000 °C.

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With advances in protein structure prediction thanks to deep learning models like AlphaFold, RNA structure prediction has recently received increased attention from deep learning researchers. RNAs introduce substantial challenges due to the sparser availability and lower structural diversity of the experimentally resolved RNA structures in comparison to protein structures. These challenges are often poorly addressed by the existing literature, many of which report inflated performance due to using training and testing sets with significant structural overlap.

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With advances in protein structure prediction thanks to deep learning models like AlphaFold, RNA structure prediction has recently received increased attention from deep learning researchers. RNAs introduce substantial challenges due to the sparser availability and lower structural diversity of the experimentally resolved RNA structures in comparison to protein structures. These challenges are often poorly addressed by the existing literature, many of which report inflated performance due to using training and testing sets with significant structural overlap.

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Centrioles are microtubule-based cylindrical ultrastructures characterized by their definite size and robustness. The molecular capping protein, CPAP (also known as CENPJ) engages its N-terminal region with the centriole microtubules to regulate their length. Nevertheless, the conserved C-terminal glycine-rich G-box of CPAP, which interacts with the centriole inner cartwheel protein STIL, is frequently mutated in primary microcephaly (MCPH) patients.

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Article Synopsis
  • The development of genetic tools for protozoan pathogens has been limited, hindering the identification of potential drug or vaccine targets using genome-wide studies.
  • Researchers created a new method for constructing yeast surface display (YSD) libraries and implemented a YSD fitness screen (YSD-FS) to find drug targets, achieving diverse libraries representing a substantial portion of the parasites' genomes.
  • Through this method, they identified interactions with the drug metronidazole and discovered that it may target multiple enzymes, paving the way for future research in discovering drug or vaccine targets and understanding pathogen interactions.
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